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Table of Cutaneous Drug Reactions

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Maculopapular(flat/slightly raised in pimples), scarlatiniform/rubelliform(red) pruritic(itchy) lesions
Benzodiazepines (BZDs) Carbamazepine, Valproate, Lamotrigine
Erythematous(red), pruritic(itchy) wheals. May progress to angio-oedema and anaphylaxis
Benzodiazepines (BZDs) Carbamazepine, Valproate
Fixed drug eruptions
Reddened round lesions which blister and crust. Hyperpigmentation may be permanent.

Lesions tend to present in same location if rechallenge
BZDs and carbamazepine
Bullous reactions
Blisters and vesicles; may be part of more generalised CDR such as vasculitis or EM complex*
Lichenoid reactions
Flat violaceous papules  resembling lichen planus
Hair loss,Thinning hair
Carbamazepine, vigabatrin, valproate, BZDs
Pigmentation changes
Colour changes may affect skin, hair, nails, mucous membranes; may be permanent
BZDs, Valproate
Abnormal sensitivity to UVA or UVB (photoallergy); may result in severe sunburn
Carbamazepine ; BZDs
Exfoliative dermatitis
Generalised redness, pruritus and eczema with exfoliation(skin peeling off); may affect whole body; also:  fever, chills, lymphadenopathy, malaise
Carbamazepine, diazepam , valproate
Small haemorrhagic macules coalescing to larger blisters and ulcers; fever, malaise, joint/muscle pain
BZDs, Carbamazepine, Valproate
Anticonvulsant hypersensitivity syndrome
Multiorgan syndrome affecting skin (exanthematous pustulation), fever, lymphadenopathy, leucocytosis(raised white cell count), hepatitis, nephritis(kidney inflammation), thrombocytopenia(low platelets), myopathy, anorexia, anaemia, pulmonary infiltrates(lung)


Erythema multiforme (EM) complex*
Sudden onset skin eruption(morbilliform) with  stomatitis, vesicles around lips and oral mucosa, fever, muscle pains, ocular involvement (SJS) and exfoliation 1-15% in SJS or >15% TEN of skin area
Carbamazepine, valproate
Erythema nodosum
Painful erythematous subcutaneous nodules; fever, malaise; general symptoms may persist for years.


SJS= Stevens- Johnson Syndrome; TEN= Toxic Epidermal Necrolysis