The Aword

  • Increase font size
  • Default font size
  • Decrease font size

Hepatic (Liver) Adverse Effects

E-mail Print PDF


Virtually all analgesic drugs are metabolised by the liver, therefore damage to this organ is associated with the majority of analgesics.

NSAIDs actually carry a relatively low risk of liver toxicity. Serious toxicity is uncommon with proper therapeutic use.

There have been isolated reports of chronic active hepatitis associated with use of salicylates.

Reye's syndrome is a rare liver condition which can be fatal.

Salicylate has been linked with this condition and use of aspirin in the under-12s is not recommended as the condition resembles subacute salicylate toxicity in children.